Focused on the historic transformations of the Caelian Hill in Rome, Caelius I: Santa Maria in Domnica, San Tommaso in Formis e il Clivus Scauri presents an interdisciplinary, deep-bore investigation into the urban, architectural, and artistic evolution of one of the city's most significant historical palimpsests. Edited by Alia Englen under the auspices of the Ministero per i Beni e le Attività Culturali and the Soprintendenza Archeologica di Roma, this volume unites contributions from archaeologists, art historians, architects, and paleopathologists. The text offers a comprehensive reinterpretation of the area's topoi, tracing its trajectory from Classical antiquity—examining pre-existing structures, insulae, and the Clivus Scauri—through its Early Medieval diaconal developments and iconic iconodule mosaic manifestos. Furthermore, the study analyzes Renaissance and Baroque patronage, notably Medicean interventions and major 17th-to-20th-century restorations. Combining archaeological field excavations, paleopathological analysis, and critical archival research, the work redefines active historical conservation.